The Effect of Theophylline with Ethylenediamine
نویسندگان
چکیده
Cheyne-Stokes respiration, found associated with cardiac failure, has been attributed to cerebral anoxia (1) on the basis of decreased cerebral blood flow, which is depressed in proportion to the decrease in cardiac output (2). Since Aminophylline increases cardiac output (3) and at the same time arrests Cheyne-Stokes respiration (4), it seems logical to conclude that the latter response occurs as a result of improvement of the cerebral circulation. However, Wechsler, Kleiss, and Kety (5) have observed that in normal individuals Aminophylline actually decreases cerebral blood flow. The following study was undertaken in order to clarify this problem. An attempt has been made to evaluate the effect of Aminophylline on the cerebral hemodynamics in 16 patients with cardiac failure, four of whom had Cheyne-Stokes respiration.
منابع مشابه
Effect of Methylxanthines on Blood Coagulation
Nonnenbruch and Szysaka quoted by Scherf and Schlackman (1946), demonstrated that intravenous injection of Theophylline Ethylenediamine increased the coagulability of blood in the rabits to a marked degree. Later on, other workers, notably Addicks and Meissner, again quoted by the same authors confirmed these observations both in animals and man, and as a result of these findings the drug was r...
متن کاملAllergy to the ethylenediamine component of aminophylline.
Intravenous aminophylline is used as a first line treatment for bronchial asthma. This preparation consists of theophylline or a salt of theophylline dissolved in a solution of ethylenediamine, which confers greater solubility and reduces the alkalinity of the drug.1 In clinical usage side effects of tachycardia, seizures and nausea are well known. We report on the much less common, but clinica...
متن کاملRequirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine.
Although the diuretic and natriuretic effects of the methylxanthines caffeine and theophylline are well established, the mechanisms responsible for these effects are unclear and may be related to inhibition of phosphodiesterases and/or antagonism of adenosine receptors. With regard to the latter, pharmacological blockade of A1 receptors can induce diuresis and natriuresis by inhibition of proxi...
متن کاملاثر بتاآگونیست تیوفیلین بر تخمگذاری و برخی ویژگیهای تخم مرغهای تخم گذار
This study was conducted to consider the effect of theophylline in laying and some of egg characteristics on laying hens. Commercial egg type Hy-Line hens were used in a completely randomize design with 4 treatments and 3 replicates for 50 days period. The levels of different theophylline supplements (treatment) were 0 (control), one, three, and five mg per kg of body weight for 50 days. The av...
متن کاملTHE EFFECT OF THEOPHYLLINE ON THE PRODUCTION OF COLONY STIMULATING FACTOR (CSF)BY THE LUNG
The effect of theophylline on colony stimulating factor production by the lung tissue was investigated. Addition of various concentrations of theophylline to the lung conditioned medium enhanced CSF production at 10 µg/ml and at higher concentrations showed an inhibitory effect. Determination of the phosphate content of the medium showed a decrease at 1-3 hours of incubation. Addition of A...
متن کاملPossible Relaxant Effects of Thymoquinone on Guinea Pig Tracheal Chain
In the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of Nigella sativa was examined in this study. The bronchodilatory effects of th...
متن کامل